## The mysterious ρ within studies [General Sta­tis­tics]

Dear Astea!

❝ The intermediate question is mentioned situation about parent drug and its metabolite - logically, the correlation for the parameters of parent drug and its metabolite should be stronger than for two different drugs tested on the same population?

Oh dear, yes! But that’s yet another story.

1e+06 simulations. Time consumed (secs)

   user  system elapsed

 979.75   95.18 1115.72

Get a faster machine! My almost three years old tin-can:
1e+06 simulations. Time consumed (secs)    user  system elapsed  208.64   31.17  240.75

❝ Do I understand correctly that in your latest code you exployed all AUC and Cmax individual data for each study in order to estimate "within rho"?

Yes. Apples and oranges. See there for a breakdown by analyte.

Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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