Bioequivalence and Bioavailability Forum

The mysterious ρ -between or within studies [General Sta­tis­tics]

posted by d_labes  – Berlin, Germany, 2018-02-11 16:57 (2258 d 12:30 ago) – Posting: # 18395
Views: 15,394

Dear Helmut! Dear all!

❝ Current state of affairs about the mysterious ρ

That's not the whole truth about the state of affairs .
The question is: Correlation of treatment differences between studies or within studies.

For the latter I recall you two references:
Phillips KF.
Power for Testing Multiple Instances of the Two One-Sided Tests Procedure
Int J Biostat. 2009;5(1):Article 15. doi:10.2202/1557-4679.1169

Hua SY, Xu S, D’Agostino RB Sr.
Multiplicity adjustments in testing for bioequivalence
Stat Med. 2015;34(2):215–31. doi:10.1002/sim.6247

Quote from Kem Phillips:
"The correlation will usually be difficult to estimate, unless a similar experiment has been conducted...".
That smells for me like within a study.

Definition in Hua et al., Section 2, clearly is within a study. Although Ben doubt the correctness of the formulas for ρ given in that paper. Note further that the observed alpha-inflation in that paper is crap. The IUT principle protects us from the need to adjust alpha.

Complete thread:

• Power and type I adjustment for 222BE when several PK prams considered Louis52 2018-02-07 21:04 [General Sta­tis­tics] 
  • Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-07 22:37
  • Power of two combined TOST d_labes 2018-02-08 14:12
    • The mysterious ρ Helmut 2018-02-08 21:40
      • ρ ρ ρ your boat ElMaestro 2018-02-09 09:58
        • ρ ρ ρ your boat Helmut 2018-02-09 19:20
      • ...and a bonus question ElMaestro 2018-02-09 11:32
        • ...and a bonus question Helmut 2018-02-09 19:43
          • If u see a BEar don't forget to R oaρ Astea 2018-02-09 20:47
            • package install failed d_labes 2018-02-11 13:23
      • The mysterious ρ -between or within studiesd_labes 2018-02-11 15:57
        • The mysterious ρ -between or within studies Helmut 2018-02-11 17:31
          • The mysterious ρ -between or within studies d_labes 2018-02-11 19:21
            • The mysterious ρ within studies Helmut 2018-02-11 22:44
              • The mysterious ρ within studies nobody 2018-02-12 09:08
        • The mysterious ρ -between or within studies Astea 2018-02-11 17:34
          • The mysterious ρ -between or within studies d_labes 2018-02-11 19:36
          • The mysterious ρ within studies Helmut 2018-02-11 22:48
  • Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-11 18:43
    • Power and type I adjustment for 222BE when several PK prams considered nobody 2018-02-12 09:10
      • reminds me of something ElMaestro 2018-02-12 09:18
        • reminds me of something nobody 2018-02-12 09:38
          • Hammer to fall Astea 2018-02-12 18:37
            • Put the sickle to the corn Helmut 2018-02-13 01:37
              • Put the sickle to the corn Astea 2018-02-13 08:27
                • Put the sickle to the corn Helmut 2018-02-13 12:45
              • Put the sickle to the corn Relaxation 2018-02-13 10:37
                • multiple units, lag-times Helmut 2018-02-13 13:31