Bioequivalence and Bioavailability Forum

If u see a BEar don't forget to R oaρ [General Sta­tis­tics]

posted by Astea – Russia, 2018-02-09 21:47 (1946 d 07:11 ago) – Posting: # 18392
Views: 15,151

Dear all!
I tried to repeat the Helmut's conclusions. I used 70 datasets from 63 2x2x2 studies. My rho is 0.797 for untransformed data and 0.799 for log-transformed. Meanwhile it tends to have the inverse situation, that is there are more values lower than 100 comparing to those uper than 100 (66% for Cmax and 63% for AUC). Suppose it is just an artefact of low sample size..


P.S. One dummy's question about PowerTOST from GitHub: while trying to do devtools::install_github("Detlew/PowerTOST") I got:
package ‘mvtnorm’ successfully unpacked and MD5 sums checked
Warning: cannot remove prior installation of package ‘mvtnorm’
In R CMD INSTALL
Installation failed: Command failed (1)

Should I delete it manually or ...what to do?

Complete thread:

• Power and type I adjustment for 222BE when several PK prams considered Louis52 2018-02-07 21:04 [General Sta­tis­tics] 
  • Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-07 22:37
  • Power of two combined TOST d_labes 2018-02-08 14:12
    • The mysterious ρ Helmut 2018-02-08 21:40
      • ρ ρ ρ your boat ElMaestro 2018-02-09 09:58
        • ρ ρ ρ your boat Helmut 2018-02-09 19:20
      • ...and a bonus question ElMaestro 2018-02-09 11:32
        • ...and a bonus question Helmut 2018-02-09 19:43
          • If u see a BEar don't forget to R oaρAstea 2018-02-09 20:47
            • package install failed d_labes 2018-02-11 13:23
      • The mysterious ρ -between or within studies d_labes 2018-02-11 15:57
        • The mysterious ρ -between or within studies Helmut 2018-02-11 17:31
          • The mysterious ρ -between or within studies d_labes 2018-02-11 19:21
            • The mysterious ρ within studies Helmut 2018-02-11 22:44
              • The mysterious ρ within studies nobody 2018-02-12 09:08
        • The mysterious ρ -between or within studies Astea 2018-02-11 17:34
          • The mysterious ρ -between or within studies d_labes 2018-02-11 19:36
          • The mysterious ρ within studies Helmut 2018-02-11 22:48
  • Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-11 18:43
    • Power and type I adjustment for 222BE when several PK prams considered nobody 2018-02-12 09:10
      • reminds me of something ElMaestro 2018-02-12 09:18
        • reminds me of something nobody 2018-02-12 09:38
          • Hammer to fall Astea 2018-02-12 18:37
            • Put the sickle to the corn Helmut 2018-02-13 01:37
              • Put the sickle to the corn Astea 2018-02-13 08:27
                • Put the sickle to the corn Helmut 2018-02-13 12:45
              • Put the sickle to the corn Relaxation 2018-02-13 10:37
                • multiple units, lag-times Helmut 2018-02-13 13:31