Bioequivalence and Bioavailability Forum

...and a bonus question [General Statistics]

posted by Helmut – Vienna, Austria, 2018-02-09 20:43 (2595 d 02:03 ago) – Posting: # 18390
Views: 17,614

Hi ElMaestro,

updated version:

[image]

Runtime 0.92 seconds. 7470 subjects in 142 data sets of 114 2×2×2 studies (86 analytes).

Evaluated by: lm(log(PK) ~ sequence+subject+period+treatment, data=study)

              PE.AUC[study]  <- exp(summary(model.AUC)$coef["treatmentT", "Estimate"])

              PE.Cmax[study] <- exp(summary(model.Cmax)$coef["treatmentT", "Estimate"])

              pearson <- cor.test(PE.Cmax, PE.AUC)

              rho     <- pearson$estimate

              CI      <- as.numeric(pearson$conf.int)

rho         : 0.6540 (95% CI: 0.5483 … 0.7391)

❝ If I look at the location of your PE's on the horisontal axis (the AUC axis) then it looks to me like there are more points on the higher side of 1 than on the lower side.

cat(sprintf("%.1f%%", 100*sum(PE.AUC > 1)/length(PE.AUC)), ">1\n"); summary(PE.AUC, digits=4)

58.5% >1

   Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 

 0.7206  0.9768  1.0110  1.0250  1.0600  1.2850

❝ Same might apply for the vertical axis, not sure. Perhaps I am only hallewcinating? :-D

❝ Perhaps it is only a graphical artifact?

cat(sprintf("%.1f%%", 100*sum(PE.Cmax > 1)/length(PE.Cmax)), ">1\n"); summary(PE.Cmax, digits=4)

57.7% >1

   Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 

 0.6692  0.9586  1.0320  1.0260  1.0950  1.3800

❝ Or something with the selection of studies plotted?

Duno. In the meantime I removed two studies (one was a tablet vs. a suspension and the other one from Hauschke/Steinijans – two MRs but the target was “flatter is better”) and added a couple more. It was easy to import the data but now I have to check in the protocols what the target was. Not always stated in the title and boring reading matter. Will take a while.

❝ If not, then I wonder why that wold be so? I imagine you don't really have the answer but I am curious about any speculation from your side or from others. My head is already abuzz with stabilities and overages and much other weird stuff from the odd sock drawer of speculation.

You are not alone. I have more questions than answers myself. Most circle around which ones to include:

Some studies failed completely and passed after re-formulation. Shall I exclude the former?
Shall I keep failed ones but with PEs within the AR (indecisive)?
etc.

Basic research is what I’m doing
when I don’t know what I’m doing. Wernher von Braun

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Power and type I adjustment for 222BE when several PK prams considered Louis52 2018-02-07 21:04 [General Statistics]
- Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-07 22:37
- Power of two combined TOST d_labes 2018-02-08 14:12
  - The mysterious ρ Helmut 2018-02-08 21:40
    - ρ ρ ρ your boat ElMaestro 2018-02-09 09:58
      - ρ ρ ρ your boat Helmut 2018-02-09 19:20
    - ...and a bonus question ElMaestro 2018-02-09 11:32
      - ...and a bonus questionHelmut 2018-02-09 19:43
        
        If u see a BEar don't forget to R oaρ Astea 2018-02-09 20:47
        
        package install failed d_labes 2018-02-11 13:23
    - The mysterious ρ -between or within studies d_labes 2018-02-11 15:57
      - The mysterious ρ -between or within studies Helmut 2018-02-11 17:31
        
        The mysterious ρ -between or within studies d_labes 2018-02-11 19:21
        
        The mysterious ρ within studies Helmut 2018-02-11 22:44
        
        The mysterious ρ within studies nobody 2018-02-12 09:08
      - The mysterious ρ -between or within studies Astea 2018-02-11 17:34
        
        The mysterious ρ -between or within studies d_labes 2018-02-11 19:36
        The mysterious ρ within studies Helmut 2018-02-11 22:48
- Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-11 18:43
  - Power and type I adjustment for 222BE when several PK prams considered nobody 2018-02-12 09:10
    - reminds me of something ElMaestro 2018-02-12 09:18
      - reminds me of something nobody 2018-02-12 09:38
        
        Hammer to fall Astea 2018-02-12 18:37
        
        Put the sickle to the corn Helmut 2018-02-13 01:37
        
        Put the sickle to the corn Astea 2018-02-13 08:27
        
        Put the sickle to the corn Helmut 2018-02-13 12:45
        
        Put the sickle to the corn Relaxation 2018-02-13 10:37
        
        multiple units, lag-times Helmut 2018-02-13 13:31

...and a bonus question [General Sta­tis­tics]

Complete thread:

...and a bonus question [General Statistics]