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RegisterAUC truncated [Design Issues]
Dear All,
I would like to know if there is a special procedure to sample collection considering AUC truncated design when the drug has a long half-life (higher than 90 hours). Is it correct collect samples for 2xt1/2? Considering t1/2 = 90h, sample collection until 180h. In this situation would be impossible to apply the concept of samples until 72h. Is it correct?
Regards,
Daniel Rossi de Campos
Brazil
I would like to know if there is a special procedure to sample collection considering AUC truncated design when the drug has a long half-life (higher than 90 hours). Is it correct collect samples for 2xt1/2? Considering t1/2 = 90h, sample collection until 180h. In this situation would be impossible to apply the concept of samples until 72h. Is it correct?
Regards,
Daniel Rossi de Campos
Brazil
Complete thread:
- AUC truncateddrcampos 2008-05-09 05:10 [Design Issues]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- AUC truncated at 72 hours Helmut 2008-05-17 16:34
- AUC truncated at 72 hours d_labes 2008-05-23 08:52
- AUC truncated at 72 hours Helmut 2008-05-23 14:09
- AUC truncated at 72 hours d_labes 2008-05-23 08:52
- AUC truncated at 72 hours Helmut 2008-05-17 16:34
Ing. Helmut Schütz