AUC=f·D/CL [Study As­sess­ment]

posted by Helmut Homepage – Vienna, Austria, 2018-02-08 20:55  – Posting: # 18383
Views: 6,027

Hi ssussu,

» As I simulate 3 condition of infusion by WinNonlin PK Modeling,
» 1. infusion by constant rate for 30min and complete the infusion at 30min;
» 2. infusion 15min and stop for 5min and speed up the infusion rate to complete at 30min;
» 3. infusion 15min and stop for 5min and keep the same infusion rate and complete at 35min.
» below is what i get:
» [image]
»
» It's different from what you have present. Now I am confused, I don't know why.:confused:

Of course it looks different. You have an enlarged time scale (one hour instead of my two) and a much faster elimination. My t½ was eight hours (k 0.0866434). Sorry to say but you should try to understand the basic concepts of PK before using such a powerful tool like Phoenix/WinNonlin. :no:

Last hint: Run NCA (lin-up/log-down trapezoidal) on the predicted data, extrapolate to infinity, and compare AUCinf of the three scenarios. What do you get?

Cheers,
Helmut Schütz
[image]

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