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RegisterAUC=f·D/CL [Study Assessment]
posted by Helmut 
– Vienna, Austria, 2018-02-08 22:55 (1877 d 07:15 ago) – Posting: # 18383
Views: 8,727
Hi ssussu,
Of course it looks different. You have an enlarged time scale (one hour instead of my two) and a much faster elimination. My t½ was eight hours (k 0.0866434). Sorry to say but you should try to understand the basic concepts of PK before using such a powerful tool like Phoenix/WinNonlin.
Last hint: Run NCA (lin-up/log-down trapezoidal) on the predicted data, extrapolate to infinity, and compare AUCinf of the three scenarios. What do you get?
❝ As I simulate 3 condition of infusion by WinNonlin PK Modeling,
❝ 1. infusion by constant rate for 30min and complete the infusion at 30min;
❝ 2. infusion 15min and stop for 5min and speed up the infusion rate to complete at 30min;
❝ 3. infusion 15min and stop for 5min and keep the same infusion rate and complete at 35min.
❝ below is what i get:
❝ [image]
❝
❝ It's different from what you have present. Now I am confused, I don't know why.
Of course it looks different. You have an enlarged time scale (one hour instead of my two) and a much faster elimination. My t½ was eight hours (k 0.0866434). Sorry to say but you should try to understand the basic concepts of PK before using such a powerful tool like Phoenix/WinNonlin.
Last hint: Run NCA (lin-up/log-down trapezoidal) on the predicted data, extrapolate to infinity, and compare AUCinf of the three scenarios. What do you get?
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
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The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- When the the infusion speed deviate from the protocol specified ssussu 2018-02-06 10:48 [Study Assessment]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Different PK profile Helmut 2018-02-06 13:28
- Different PK profile ssussu 2018-02-07 02:50
- Different PK profile Helmut 2018-02-07 11:04
- Different PK profile ssussu 2018-02-07 11:42
- Suitable equipment? Helmut 2018-02-07 14:13
- Suitable equipment? ssussu 2018-02-08 04:07
- AUC=f·D/CL Helmut 2018-02-08 10:28
- AUC=f·D/CL ssussu 2018-02-08 11:21
- AUC=f·D/CLHelmut 2018-02-08 21:55
- AUC=f·D/CL ssussu 2018-02-09 00:31
- AUC=f·D/CLHelmut 2018-02-08 21:55
- AUC=f·D/CL ssussu 2018-02-08 11:21
- AUC=f·D/CL Helmut 2018-02-08 10:28
- Suitable equipment? ssussu 2018-02-08 04:07
- Suitable equipment? Helmut 2018-02-07 14:13
- Different PK profile ssussu 2018-02-07 11:42
- Different PK profile Helmut 2018-02-07 11:04
- Different PK profile ssussu 2018-02-07 02:50
- When the the infusion speed deviate from the protocol specified ElMaestro 2018-02-07 13:20
- When the the infusion speed deviate from the protocol specified ssussu 2018-02-08 04:23
- Different PK profile Helmut 2018-02-06 13:28
Ing. Helmut Schütz