Bioequivalence and Bioavailability Forum

AUC=f·D/CL [Study As­sess­ment]

posted by ssussu – China, 2018-02-08 12:21 (1874 d 19:13 ago) – Posting: # 18380
Views: 9,027

Hi Helmut,

As I simulate 3 condition of infusion by WinNonlin PK Modeling,
1. infusion by constant rate for 30min and complete the infusion at 30min;
2. infusion 15min and stop for 5min and speed up the infusion rate to complete at 30min;
3. infusion 15min and stop for 5min and keep the same infusion rate and complete at 35min.
below is what i get:


It's different from what you have present. Now I am confused, I don't know why.
Hope to discuss with you more.

Complete thread:

• When the the infusion speed deviate from the protocol specified ssussu 2018-02-06 10:48 [Study As­sess­ment] 
  • Different PK profile Helmut 2018-02-06 13:28
    • Different PK profile ssussu 2018-02-07 02:50
      • Different PK profile Helmut 2018-02-07 11:04
        • Different PK profile ssussu 2018-02-07 11:42
          • Suitable equipment? Helmut 2018-02-07 14:13
            • Suitable equipment? ssussu 2018-02-08 04:07
              • AUC=f·D/CL Helmut 2018-02-08 10:28
                • AUC=f·D/CLssussu 2018-02-08 11:21
                  • AUC=f·D/CL Helmut 2018-02-08 21:55
                    • AUC=f·D/CL ssussu 2018-02-09 00:31
  • When the the infusion speed deviate from the protocol specified ElMaestro 2018-02-07 13:20
    • When the the infusion speed deviate from the protocol specified ssussu 2018-02-08 04:23