Bioequivalence and Bioavailability Forum • Different PK profile

Different PK profile [Study Assessment]

posted by Helmut – Vienna, Austria, 2018-02-07 12:04 (2411 d 10:40 ago) – Posting: # 18368
Views: 9,981

Hi ssussu,

❝ The dose is not lost because the nurse expel the burble by squeezing the tube to float the burble up from the liquid surface of the tube.

I don’t understand. Did you use an infusion pump or an infusion bottle / drip chamber?

❝ ❝ 2. only if you lost nothing […] the C_max and AUC will equal the one with a constant rate infusion.

❝ ❝

❝ ❝

[image]

❝

❝ From the above picture, if the dose is not lost, can i say just the AUC will be effect but the Cmax is the same with the canstant rate infusion?

Read again what I wrote above.

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Complete thread:

When the the infusion speed deviate from the protocol specified ssussu 2018-02-06 10:48 [Study Assessment]
- Different PK profile Helmut 2018-02-06 13:28
  - Different PK profile ssussu 2018-02-07 02:50
    - Different PK profileHelmut 2018-02-07 11:04
      - Different PK profile ssussu 2018-02-07 11:42
        
        Suitable equipment? Helmut 2018-02-07 14:13
        
        Suitable equipment? ssussu 2018-02-08 04:07
        
        AUC=f·D/CL Helmut 2018-02-08 10:28
        
        AUC=f·D/CL ssussu 2018-02-08 11:21
        
        AUC=f·D/CL Helmut 2018-02-08 21:55
        
        AUC=f·D/CL ssussu 2018-02-09 00:31
- When the the infusion speed deviate from the protocol specified ElMaestro 2018-02-07 13:20
  - When the the infusion speed deviate from the protocol specified ssussu 2018-02-08 04:23

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