Different PK profile [Study As­sess­ment]

posted by ssussu – China, 2018-02-07 02:50  – Posting: # 18365
Views: 6,643

Hi Helmut,

Thanks for your reply.

» Be aware that the dose will not be correct since likely you lost a part by flushing the tube. Whether this is really relevant depends on the lost volume / total infusion volume.

The dose is not lost because the nurse expel the burble by squeezing the tube to float the burble up from the liquid surface of the tube.

» 2. only if you lost nothing […] the Cmax and AUC will equal the one with a constant rate infusion.
»
» Example: t½ 8 h, infusion interrupted after 15 min for 5 minutes, adjusted infusion rate, no dose lost.
»
»

[image]



From the above picture, if the dose is not lost, can i say just the AUC will be effect but the Cmax is the same with the canstant rate infusion?


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

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