Different PK profile [Study As­sess­ment]

posted by ssussu – China, 2018-02-07 02:50  – Posting: # 18365
Views: 6,259

Hi Helmut,

Thanks for your reply.

» Be aware that the dose will not be correct since likely you lost a part by flushing the tube. Whether this is really relevant depends on the lost volume / total infusion volume.

The dose is not lost because the nurse expel the burble by squeezing the tube to float the burble up from the liquid surface of the tube.

» 2. only if you lost nothing […] the Cmax and AUC will equal the one with a constant rate infusion.
»
» Example: t½ 8 h, infusion interrupted after 15 min for 5 minutes, adjusted infusion rate, no dose lost.
»
»

[image]



From the above picture, if the dose is not lost, can i say just the AUC will be effect but the Cmax is the same with the canstant rate infusion?


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,871 posts in 4,212 threads, 1,364 registered users;
online 11 (0 registered, 11 guests [including 8 identified bots]).
Forum time (Europe/Vienna): 13:09 CEST

Multivariate analysis: A means of finding the answer
when you don’t know the question.    Stephen Senn

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5