Different PK profile [Study As­sess­ment]

posted by ssussu – China, 2018-02-07 03:50 (2295 d 00:42 ago) – Posting: # 18365
Views: 9,548

Hi Helmut,

Thanks for your reply.

❝ Be aware that the dose will not be correct since likely you lost a part by flushing the tube. Whether this is really relevant depends on the lost volume / total infusion volume.


The dose is not lost because the nurse expel the burble by squeezing the tube to float the burble up from the liquid surface of the tube.

❝ 2. only if you lost nothing […] the Cmax and AUC will equal the one with a constant rate infusion.


❝ Example: t½ 8 h, infusion interrupted after 15 min for 5 minutes, adjusted infusion rate, no dose lost.


[image]



From the above picture, if the dose is not lost, can i say just the AUC will be effect but the Cmax is the same with the canstant rate infusion?


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
23,033 posts in 4,835 threads, 1,647 registered users;
39 visitors (0 registered, 39 guests [including 5 identified bots]).
Forum time: 05:32 CEST (Europe/Vienna)

Give me a fruitful error any time, full of seeds, bursting with its own corrections.
You can keep your sterile truth for yourself.    Vilfredo Pareto

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5