Different PK profile [Study Assessment]
Hi Helmut,
Thanks for your reply.
The dose is not lost because the nurse expel the burble by squeezing the tube to float the burble up from the liquid surface of the tube.
From the above picture, if the dose is not lost, can i say just the AUC will be effect but the Cmax is the same with the canstant rate infusion?
Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]
Thanks for your reply.
❝ Be aware that the dose will not be correct since likely you lost a part by flushing the tube. Whether this is really relevant depends on the lost volume / total infusion volume.
The dose is not lost because the nurse expel the burble by squeezing the tube to float the burble up from the liquid surface of the tube.
❝ 2. only if you lost nothing […] the Cmax and AUC will equal the one with a constant rate infusion.
❝
❝ Example: t½ 8 h, infusion interrupted after 15 min for 5 minutes, adjusted infusion rate, no dose lost.
❝
❝
From the above picture, if the dose is not lost, can i say just the AUC will be effect but the Cmax is the same with the canstant rate infusion?
Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]
Complete thread:
- When the the infusion speed deviate from the protocol specified ssussu 2018-02-06 10:48 [Study Assessment]
- Different PK profile Helmut 2018-02-06 13:28
- Different PK profilessussu 2018-02-07 02:50
- Different PK profile Helmut 2018-02-07 11:04
- Different PK profile ssussu 2018-02-07 11:42
- Suitable equipment? Helmut 2018-02-07 14:13
- Suitable equipment? ssussu 2018-02-08 04:07
- AUC=f·D/CL Helmut 2018-02-08 10:28
- AUC=f·D/CL ssussu 2018-02-08 11:21
- AUC=f·D/CL Helmut 2018-02-08 21:55
- AUC=f·D/CL ssussu 2018-02-09 00:31
- AUC=f·D/CL Helmut 2018-02-08 21:55
- AUC=f·D/CL ssussu 2018-02-08 11:21
- AUC=f·D/CL Helmut 2018-02-08 10:28
- Suitable equipment? ssussu 2018-02-08 04:07
- Suitable equipment? Helmut 2018-02-07 14:13
- Different PK profile ssussu 2018-02-07 11:42
- Different PK profile Helmut 2018-02-07 11:04
- Different PK profilessussu 2018-02-07 02:50
- When the the infusion speed deviate from the protocol specified ElMaestro 2018-02-07 13:20
- When the the infusion speed deviate from the protocol specified ssussu 2018-02-08 04:23
- Different PK profile Helmut 2018-02-06 13:28