Bioequivalence and Bioavailability Forum

Common sense [🇷 for BE/BA]

posted by Helmut  – Vienna, Austria, 2018-01-28 01:27 (2279 d 06:33 ago) – Posting: # 18298
Views: 13,397

Hi ElMaestro,

excellent post, especially re. burgers and toilet paper (another odd couple)!

When it comes to pooling of CVs you are absolutely right – and got it terribly wrong.

Do you remember what you wrote a while ago? In an earlier post I wrote:

❝ Doing the math is just the first step. Before you pool CVs I would suggest to inspect whether the confidence intervals of the CVs overlap […]. If not, try to find out why (different CROs, populations, bioanalytical methods, …). Use common sense to decide which CVs are reliable enough to pool.

That’s what statistics is all about – numbers. But never forget the data generating process. Are results obtained by a method of a reputable CRO whose head wrote dozens of papers about trace-MS better than colorimetry done in a back yard lab in Timbuktu? Etc. etc.

I suppose it is tempting, if the only tool you have is a hammer,
to treat everything as if it were a nail.     Abraham Maslow (The Psychology of Science, 1966)

See also this one. Again: Statistics is just one tool, common sense is another. Use both.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• Function CVpooled (package PowerTOST) Elena777 2018-01-21 08:53 
  • Function CVpooled (lengthy answer) Helmut 2018-01-21 17:21
    • Function CVpooled (lengthy answer) Elena777 2018-01-27 10:11
  • Function CVpooled (package PowerTOST) ElMaestro 2018-01-27 22:28
    • Common senseHelmut 2018-01-28 00:27
      • Common sense ElMaestro 2018-01-28 08:43
        • Alzheimer’s Helmut 2018-01-28 11:38
    • To pool or not to pool d_labes 2018-01-28 13:52
  • Function CVpooled (package PowerTOST) ElMaestro 2018-01-29 00:07
    • Pooling is fooling? Helmut 2018-01-29 17:53
      • Pooling is fooling? nobody 2018-01-29 19:21
        • Life is good ElMaestro 2018-01-30 18:23
          • Life is good nobody 2018-01-30 18:31
            • OT: Flags Helmut 2018-01-31 01:47
              • OT: Flags nobody 2018-01-31 10:17
                • OT: Flags ElMaestro 2018-01-31 11:02
                • OT: Flags Helmut 2018-01-31 11:16
                  • OT: Flags nobody 2018-01-31 11:22
                    • OT: Flags Helmut 2018-01-31 11:38
                      • OT: Flags nobody 2018-01-31 12:28
                        • OT: Flags Helmut 2018-01-31 17:18
                          • OT: Flags nobody 2018-01-31 17:32
                            • OT: Flags Helmut 2018-01-31 19:00