Line extension [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2018-01-23 18:40 (1888 d 23:44 ago) – Posting: # 18278
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Hi Mikkabel,

Luckily you are not exceeding the recommended dose of the originator. Hence, I would opt for a simple line extension (T2 vs. 2×T1) since you can expect a better match than in BE – which is possible as well (T2 vs. 2×R).
I don’t see how you could perform a dose-proportionality study with just two levels (zero degrees of freedom).

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