Line extension [Design Issues]
Hi Mikkabel,
Luckily you are not exceeding the recommended dose of the originator. Hence, I would opt for a simple line extension (T2 vs. 2×T1) since you can expect a better match than in BE – which is possible as well (T2 vs. 2×R).
I don’t see how you could perform a dose-proportionality study with just two levels (zero degrees of freedom).
Luckily you are not exceeding the recommended dose of the originator. Hence, I would opt for a simple line extension (T2 vs. 2×T1) since you can expect a better match than in BE – which is possible as well (T2 vs. 2×R).
I don’t see how you could perform a dose-proportionality study with just two levels (zero degrees of freedom).
—
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Choice of comparator Mikkabel 2018-01-23 17:29 [Design Issues]
- Line extensionHelmut 2018-01-23 17:40
- Proportionality and regression mittyri 2018-01-23 18:30
- Proportionality and regression Helmut 2018-01-23 18:41
- Line extension Mikkabel 2018-01-24 10:17
- Type II variation Helmut 2018-01-24 11:56
- Proportionality and regression mittyri 2018-01-23 18:30
- Line extensionHelmut 2018-01-23 17:40