Substrate for CYP1A1? [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2018-01-22 19:43 (1890 d 04:30 ago) – Posting: # 18252
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Hi Relaxation,

I agree. In general I would not worry too much about including mild to moderate smokers unless a drug is mainly (!) metabolized by CYP1A1.

@Norah: Check the literature whether diclofenac is a substrate for CYP1A1 (I don’t think so).

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