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RegisterCVwithin calculation of biperiden [Power / Sample Size]
Hello,
I am trying to find the CVwithin of biperiden immediate release but I am struggling to find any literature on bioequivalence of biperiden. However, I found a cross-over study comparing pharmacokinetics of biperiden immediate release against extended release.
Is it reasonable to assume the CVwithin of biperiden to be equal to the one on the study that I found? I mean, I think it will be smaller or equal at most, therefore if I assume it is the same for the sake of sample size calculation, I could be overestimating sample size, but I would not be sacrificing any statistical power, which is not statistically incorrect, right?
Any help is welcome.
many thanks
I am trying to find the CVwithin of biperiden immediate release but I am struggling to find any literature on bioequivalence of biperiden. However, I found a cross-over study comparing pharmacokinetics of biperiden immediate release against extended release.
Is it reasonable to assume the CVwithin of biperiden to be equal to the one on the study that I found? I mean, I think it will be smaller or equal at most, therefore if I assume it is the same for the sake of sample size calculation, I could be overestimating sample size, but I would not be sacrificing any statistical power, which is not statistically incorrect, right?
Any help is welcome.
many thanks
Complete thread:
- CVwithin calculation of biperidenCECIF 2018-01-17 20:44 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- pooled CV from MR vs. IR Helmut 2018-01-18 16:46
- pooled CV from MR vs. IR ElMaestro 2018-01-18 17:03
- pooled CV from MR vs. IR jag009 2018-01-21 03:32
- pooled CV from MR vs. IR Yura 2018-01-19 10:05
- TSD: BE in stage 1 Helmut 2018-01-19 12:21
- TSD: BE in stage 1 Yura 2018-01-19 13:21
- TSD: BE in stage 1 Helmut 2018-01-19 12:21
- pooled CV from MR vs. IR ElMaestro 2018-01-18 17:03
- pooled CV from MR vs. IR Helmut 2018-01-18 16:46
Ing. Helmut Schütz