Bioequivalence and Bioavailability Forum

Hi ElMaestro,

❝ "because of reasons"

❝

❝ etc. etc. etc.

❝

❝ Yes, life would be easier if the guy using the data you are submitting would be as IT-literate as you are.

I have no technical problems preparing the data in this format. What I find hard to swallow is that I

1. have to manipulate (!) the data (my files contain the string BQL for all values <LLOQ after t_max) and
   
2. have no means to give actual sampling times.

Concerning #1 hopefully HC’s software is “clever” enough to ignore late BQLs (replaced by zeros) and will not add a triangle after t_last (i.e., apply Pharsight’s unspeakable invention AUC_all instead of AUC_last). #2 will always lead to discrepancies to my results since I abandoned using scheduled sampling times in NCA decades ago.

❝ Well, life just isn't always optimal

All too true.

BTW, another goody in Section 11.4.2

The regression lines, based upon at least four points during the terminal log-linear phase of the curve, used to estimate the terminal disposition rate constant (λ) should also be displayed.

Oops!