Imbalanced randomization sequence before conducting the study [Design Issues]

posted by Mohamed Yehia  – Egypt, 2018-01-11 17:19 (2353 d 08:06 ago) – Posting: # 18168
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Hi All,

Is it possible to make imbalanced Randomization sequence before entering the study?

For example, using 33 subjects for 2 treatment, 2 sequence, 4 period cross over study.

In my opinion, I don't accept this as despite the fact of the possibility of getting imbalanced sequence as a result of subject withdrawal, but I think that this does not mean that it is acceptable to perform imbalanced randomization from the beginning.

I want your opinion asap.

Thanks


Edit: Relax; see also this post #9. [Helmut]

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