Distinguish accumulation [NCA / SHAM]

posted by oksanachlebko – Ukraine, 2018-01-05 01:10 (2359 d 22:27 ago) – Posting: # 18146
Views: 8,711

Dear Helmut!
I kindly ask you to help me with the following question!

❝ If I get an accumulation index in the MD study more or less different from 1 I try to give additional information, whether the drug shows true nonlinear PK, or only a small shift due to the second compartment.


is it possible to distinguish true nonlinear PK and shift due to other compartments?
What if the dose proportionality is proven but accumulation index is more than 1.4?

All the Best!
Oksana

Complete thread:

UA Flag
Activity
 Admin contact
23,059 posts in 4,841 threads, 1,663 registered users;
38 visitors (0 registered, 38 guests [including 5 identified bots]).
Forum time: 00:38 CEST (Europe/Vienna)

[…] an inappropriate study design is incapable of answering
a research question, no matter how careful the subsequent
methodology, conduct, analysis, and interpretation:
Flawless execution of a flawed design achieves nothing worthwhile.    J. Rick Turner

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5