Bioequivalence and Bioavailability Forum • qt in WinNonlin

qt in WinNonlin [Software]

posted by mittyri – Russia, 2018-01-05 00:13 (2096 d 15:08 ago) – Posting: # 18144
Views: 10,430

Hi Antigoni and Helmut,

That's really weird.
As I see the problem is in quantile function, looks like approximation is not correct for low DF.

R:

qt(0.025, 1:7)

[1] -12.706205  -4.302653  -3.182446  -2.776445  -2.570582

[6]  -2.446912  -2.364624

WNL 502:

For compliance the same solution could be implemented as R did:
For central qt, a C translation of
Hill, G. W. (1970) Algorithm 396: Student's t-quantiles. Communications of the ACM, 13(10), 619–620.
altered to take account of
Hill, G. W. (1981) Remark on Algorithm 396, ACM Transactions on Mathematical Software, 7, 250–1.

—
Kind regards,
Mittyri

Complete thread:

assessment of steady state in WinNonLin pkpdpkpd 2007-04-04 22:52 [Software]
- steady state in WinNonlin (example) Helmut 2007-04-05 02:30
  - steady state in WinNonlin (example) pkpdpkpd 2007-04-05 16:33
    - steady state in WinNonlin (example) Helmut 2007-04-05 17:16
      - steady state in WinNonlin (example) pkpdpkpd 2007-04-05 17:39
        
        steady state in WinNonlin… Helmut 2007-04-05 18:40
        
        steady state in WinNonlin… pkpdpkpd 2007-04-05 21:37
        Paired Design in WinNonlin Helmut 2007-04-06 00:23
  - steady state in WinNonlin (example) apapanas 2018-01-03 14:44
    - steady state in WinNonlin (example) Helmut 2018-01-04 17:11
      - qt in WinNonlinmittyri 2018-01-04 23:13
        
        ‘Deep’ bug Helmut 2018-01-05 00:37
        Workarounds for v6.3+ Helmut 2018-01-08 00:40
        
        Workarounds for v6.3+ apapanas 2018-01-10 12:47