“Forced BE” 101 [Power / Sample Size]

posted by kms.srinivas – India, 2017-12-27 11:41 (1271 d 00:39 ago) – Posting: # 18098
Views: 30,368

(edited by kms.srinivas on 2017-12-27 12:12)

Dear Helmut,
Much pleasure with your reply.

» study planned for 90% power: The chance to obtain a post hoc power of ≥95% is ~35%.

Is it a thumb rule? how it should be calculated?

» It only means that
»    – the CV was lower and/or
»    – the GMR closer to 1 and/or
»    – you had less dropouts than assumed.

Yes, on getting posthoc analysis, i found three aspects what you said:
After experiment, it came to know that
1. CV getting lower
2. GMR close to 1
3. No dropouts/withdrawls (though prior consideration of 10% dropouts)

Complete thread:

 Admin contact
21,530 posts in 4,499 threads, 1,523 registered users;
online 17 (0 registered, 17 guests [including 2 identified bots]).
Forum time: Sunday 12:21 UTC (Europe/Vienna)

Intellect distinguishes between the possible and the impossible;
reason distinguishes between the sensible and the senseless.
Even the possible can be senseless.    Max Born

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz