PK parameters from multiple doses [PK / PD]

posted by nobody – 2017-11-28 12:51 (2394 d 22:33 ago) – Posting: # 18018
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Without ANY prior knowledge on the compound:

Assume you have data only for Day 15. Samples obtained on this single day (24 h), no subsequent sampling. If the t1/2 is SO long that you havn't reached steady state by Day 15, no chance to describe this t1/2 (with model or otherwise) reliable from data obtained within 24 h sampling period. ;-)

But as long as we have no idea on the prior knowledge on the compound/formulation we are talking about, all this is somewhat academic :-D

Kindest regards, nobody

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