Bioequivalence and Bioavailability Forum

PK parameters from multiple doses [PK / PD]

posted by nobody – 2017-11-28 12:51 (2018 d 03:17 ago) – Posting: # 18018
Views: 8,314

Without ANY prior knowledge on the compound:

Assume you have data only for Day 15. Samples obtained on this single day (24 h), no subsequent sampling. If the t1/2 is SO long that you havn't reached steady state by Day 15, no chance to describe this t1/2 (with model or otherwise) reliable from data obtained within 24 h sampling period.

But as long as we have no idea on the prior knowledge on the compound/formulation we are talking about, all this is somewhat academic

Complete thread:

• Single PK parameters from multiple PK parameters asjrm 2017-11-19 00:44 [PK / PD] 
  • Single PK parameters from multiple PK parameters jag009 2017-11-19 06:32
  • PK parameters from multiple doses Helmut 2017-11-19 10:24
    • PK parameters from multiple doses Yura 2017-11-21 11:48
    • PK parameters from multiple doses SDavis 2017-11-24 10:59
      • PK parameters from multiple doses nobody 2017-11-24 16:07
        • PK parameters from multiple doses SDavis 2017-11-24 22:09
          • PK parameters from multiple doses nobody 2017-11-27 14:13
            • PK parameters from multiple doses SDavis 2017-11-28 11:34
              • PK parameters from multiple dosesnobody 2017-11-28 11:51
                • PK parameters from multiple doses SDavis 2017-11-28 11:54
  • Single PK parameters from multiple PK parameters nobody 2017-11-21 14:54