PK parameters from multiple doses [PK / PD]
Without ANY prior knowledge on the compound:
Assume you have data only for Day 15. Samples obtained on this single day (24 h), no subsequent sampling. If the t1/2 is SO long that you havn't reached steady state by Day 15, no chance to describe this t1/2 (with model or otherwise) reliable from data obtained within 24 h sampling period.
But as long as we have no idea on the prior knowledge on the compound/formulation we are talking about, all this is somewhat academic
Assume you have data only for Day 15. Samples obtained on this single day (24 h), no subsequent sampling. If the t1/2 is SO long that you havn't reached steady state by Day 15, no chance to describe this t1/2 (with model or otherwise) reliable from data obtained within 24 h sampling period.

But as long as we have no idea on the prior knowledge on the compound/formulation we are talking about, all this is somewhat academic

—
Kindest regards, nobody
Kindest regards, nobody
Complete thread:
- Single PK parameters from multiple PK parameters asjrm 2017-11-19 00:44 [PK / PD]
- Single PK parameters from multiple PK parameters jag009 2017-11-19 06:32
- PK parameters from multiple doses Helmut 2017-11-19 10:24
- PK parameters from multiple doses Yura 2017-11-21 11:48
- PK parameters from multiple doses SDavis 2017-11-24 10:59
- PK parameters from multiple doses nobody 2017-11-24 16:07
- PK parameters from multiple doses SDavis 2017-11-24 22:09
- PK parameters from multiple doses nobody 2017-11-27 14:13
- PK parameters from multiple doses SDavis 2017-11-28 11:34
- PK parameters from multiple dosesnobody 2017-11-28 11:51
- PK parameters from multiple doses SDavis 2017-11-28 11:54
- PK parameters from multiple dosesnobody 2017-11-28 11:51
- PK parameters from multiple doses SDavis 2017-11-28 11:34
- PK parameters from multiple doses nobody 2017-11-27 14:13
- PK parameters from multiple doses SDavis 2017-11-24 22:09
- PK parameters from multiple doses nobody 2017-11-24 16:07
- Single PK parameters from multiple PK parameters nobody 2017-11-21 14:54