Bioequivalence and Bioavailability Forum • Single PK parameters from multiple PK parameters

Single PK parameters from multiple PK parameters [PK / PD]

posted by nobody – 2017-11-21 15:54 (2025 d 01:14 ago) – Posting: # 17998
Views: 8,682

Assuming you are in steady-state on day 15 (and linear PK/no induction, of course), the AUC over the dosing interval on Day 15 should equal the AUC0-oo of a single dose.

To estimate the Cmax following single-dose you would need to sample on Day 1 imho...

—
Kindest regards, nobody

Complete thread:

Single PK parameters from multiple PK parameters asjrm 2017-11-19 00:44 [PK / PD]
- Single PK parameters from multiple PK parameters jag009 2017-11-19 06:32
- PK parameters from multiple doses Helmut 2017-11-19 10:24
  - PK parameters from multiple doses Yura 2017-11-21 11:48
  - PK parameters from multiple doses SDavis 2017-11-24 10:59
    - PK parameters from multiple doses nobody 2017-11-24 16:07
      - PK parameters from multiple doses SDavis 2017-11-24 22:09
        
        PK parameters from multiple doses nobody 2017-11-27 14:13
        
        PK parameters from multiple doses SDavis 2017-11-28 11:34
        
        PK parameters from multiple doses nobody 2017-11-28 11:51
        
        PK parameters from multiple doses SDavis 2017-11-28 11:54
- Single PK parameters from multiple PK parametersnobody 2017-11-21 14:54