Bioequivalence and Bioavailability Forum • Single PK parameters from multiple PK parameters

Single PK parameters from multiple PK parameters [PK / PD]

posted by jag009 – NJ, 2017-11-19 07:32 (2027 d 08:59 ago) – Posting: # 17989
Views: 8,596

❝ The researcher wants me to estimate the PK parameters of the single dose from the blood concentrations of multiple dosing.

❝ is this possible?

1) Do you know the half-life of this drug?
2) Was there drug accumulation?
3) Is the elimination kinetic complicated (i.e, biphasic elimination)

J

Complete thread:

Single PK parameters from multiple PK parameters asjrm 2017-11-19 00:44 [PK / PD]
- Single PK parameters from multiple PK parametersjag009 2017-11-19 06:32
- PK parameters from multiple doses Helmut 2017-11-19 10:24
  - PK parameters from multiple doses Yura 2017-11-21 11:48
  - PK parameters from multiple doses SDavis 2017-11-24 10:59
    - PK parameters from multiple doses nobody 2017-11-24 16:07
      - PK parameters from multiple doses SDavis 2017-11-24 22:09
        
        PK parameters from multiple doses nobody 2017-11-27 14:13
        
        PK parameters from multiple doses SDavis 2017-11-28 11:34
        
        PK parameters from multiple doses nobody 2017-11-28 11:51
        
        PK parameters from multiple doses SDavis 2017-11-28 11:54
- Single PK parameters from multiple PK parameters nobody 2017-11-21 14:54

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