Single PK parameters from multiple PK parameters [PK / PD]

posted by asjrm – UK, 2017-11-19 01:44 (2321 d 08:50 ago) – Posting: # 17988
Views: 9,956

Hi
I am conducting a PK study where multiple doses are given morning and night for 14 days and blood concentrations are measured at pre-dose, 0.5,1,2,3,6,12,24 hours on day 15. The last dose is given on day 15 morning.
The researcher wants me to estimate the PK parameters of the single dose from the blood concentrations of multiple dosing.
is this possible?

Thank you in advance.


Edit: Category changed; see also this post #1. [Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,640 registered users;
99 visitors (0 registered, 99 guests [including 12 identified bots]).
Forum time: 10:34 CET (Europe/Vienna)

Nothing shows a lack of mathematical education more
than an overly precise calculation.    Carl Friedrich Gauß

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5