Bioequivalence and Bioavailability Forum • Single PK parameters from multiple PK parameters

Single PK parameters from multiple PK parameters [PK / PD]

posted by asjrm – UK, 2017-11-19 01:44 (2343 d 11:41 ago) – Posting: # 17988
Views: 10,062

Hi
I am conducting a PK study where multiple doses are given morning and night for 14 days and blood concentrations are measured at pre-dose, 0.5,1,2,3,6,12,24 hours on day 15. The last dose is given on day 15 morning.
The researcher wants me to estimate the PK parameters of the single dose from the blood concentrations of multiple dosing.
is this possible?

Thank you in advance.

Edit: Category changed; see also this post #1. [Helmut]

Complete thread:

Single PK parameters from multiple PK parametersasjrm 2017-11-19 00:44 [PK / PD]
- Single PK parameters from multiple PK parameters jag009 2017-11-19 06:32
- PK parameters from multiple doses Helmut 2017-11-19 10:24
  - PK parameters from multiple doses Yura 2017-11-21 11:48
  - PK parameters from multiple doses SDavis 2017-11-24 10:59
    - PK parameters from multiple doses nobody 2017-11-24 16:07
      - PK parameters from multiple doses SDavis 2017-11-24 22:09
        
        PK parameters from multiple doses nobody 2017-11-27 14:13
        
        PK parameters from multiple doses SDavis 2017-11-28 11:34
        
        PK parameters from multiple doses nobody 2017-11-28 11:51
        
        PK parameters from multiple doses SDavis 2017-11-28 11:54
- Single PK parameters from multiple PK parameters nobody 2017-11-21 14:54