calculation of 90% CI for continuous variable in clinical endpoint studies [General Sta­tis­tics]

posted by ElMaestro  – Denmark, 2017-11-18 22:17 (2027 d 11:49 ago) – Posting: # 17987
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Hi GM,

the tradition is to use 80.00%-125.00% for a ratio of continuous variables. This makes extremely good sense under a certain set of assumptions.

You refer to section 21 of the guidance, but this does not relate to continuous variables. It applies to dichotomous variables instead.

Rule of thumb: For a difference, the acceptance range is symmetric. For a ratio the lower acceptance limit equals the reciprocal upper limit, naturally. Most BE issues you will come across have elements of both if logs are involved.

Pass or fail!

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