Bioequivalence and Bioavailability Forum

Scientific gut feeling [Two-Stage / GS Designs]

posted by d_labes  – Berlin, Germany, 2017-11-15 10:34 (1105 d 08:14 ago) – Posting: # 17981
Views: 6,479

Dear Helmut,

» My gut feeling tells me:

Woman are better in gut feeling, NLYW especially .

» The adjusted α showed (well, in simulations…) that the TIE is controlled if we follow the frameworks exactly, i.e., initiate the second stage only if necessary based on the interim and with the re-estimated sample size. If we increase the sample size, the chance of passing BE increases and hence, the TIE.

Wait, wait ... I will be back in 5 min with some quick shoot code to verify your claim.

Meanwhile prepare a decision scheme with two metrics. So that I can see if my implementation is correct. My brain gets crowded if I think about the decision scheme. So many "What if". And here you are trained as scuba diver I was told from somebody .

Complete thread:

• Two PK metrics: Inflation of the Type I Error Helmut 2017-11-12 11:57 
  • Two PK metrics: Inflation of the Type I Error? d_labes 2017-11-12 17:46
  • A place to start ElMaestro 2017-11-12 21:43
    • A place to start? d_labes 2017-11-13 16:02
      • A place to start? Helmut 2017-11-13 16:51
        • Scientific gut feelingd_labes 2017-11-15 10:34
          • Five minutes gone - power.tsd.2m() arose d_labes 2017-11-15 13:15
      • A better place to start. ElMaestro 2017-11-14 00:04
        • Nope Helmut 2017-11-14 00:21
          • Nope nobody 2017-11-14 08:11
          • I've meditated hard ElMaestro 2017-11-14 12:41