I've meditated hard [Two-Stage / GS Designs]
Hi Hötzi,
Can you reformulate?
I meditated hard and I don't see why my suggestion does not address it. It will treat AUCt as if it having a higher CV for everything except BE evaluation. It is if I get your question correctly exactly what is going on.
So perhaps I did not understand you. While I sit in Lotus position and humming gently, do you think you could somehow put other words to the part I don't get?
❝ That’s not my point. Meditate over my example. We would initiate the second stage with 28 subjects (driven by the CV of Cmax 0.30) but should stop after the first stage for AUC (CV 0.20).
Can you reformulate?
I meditated hard and I don't see why my suggestion does not address it. It will treat AUCt as if it having a higher CV for everything except BE evaluation. It is if I get your question correctly exactly what is going on.
So perhaps I did not understand you. While I sit in Lotus position and humming gently, do you think you could somehow put other words to the part I don't get?
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Two PK metrics: Inflation of the Type I Error Helmut 2017-11-12 11:57
- Two PK metrics: Inflation of the Type I Error? d_labes 2017-11-12 17:46
- A place to start ElMaestro 2017-11-12 21:43
- A place to start? d_labes 2017-11-13 16:02
- A place to start? Helmut 2017-11-13 16:51
- Scientific gut feeling d_labes 2017-11-15 10:34
- Five minutes gone - power.tsd.2m() arose d_labes 2017-11-15 13:15
- Scientific gut feeling d_labes 2017-11-15 10:34
- A better place to start. ElMaestro 2017-11-14 00:04
- A place to start? Helmut 2017-11-13 16:51
- A place to start? d_labes 2017-11-13 16:02