Nope [Two-Stage / GS Designs]

posted by Helmut Homepage – Vienna, Austria, 2017-11-14 00:21 (1277 d 17:15 ago) – Posting: # 17977
Views: 7,146

Hi ElMaestro,

» Best I can come up with is as follows:
» The only thing that determines the need for for stage 2 is the CV. :blahblah:
»
» So run the sims in the usual fashion, but add 5-20 points on the CV for the power and sample size estimation.

That’s not my point. Meditate over my example. We would initiate the second stage with 28 subjects (driven by the CV of Cmax 0.30) but should stop after the first stage for AUC (CV 0.20).

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Helmut Schütz
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