A place to start? [Two-Stage / GS Designs]

posted by d_labes  – Berlin, Germany, 2017-11-13 15:02 (1204 d 12:55 ago) – Posting: # 17974
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Dear ElMaestro,

» can you run a series of sims where you include "20 more subjects than necessary" in stage 2 where a stage 2 is called for?

that could indeed be done within the (in)famous package Power2Stage, function power.2stage.fC() using the argument n2.min. At least partially because n2.min assures a minimum sample size for stage 2, if stage 2 is called for and the estimated sample size is smaller than n2.min.

But that's not the problem Helmut has described, at least as I understand it. Here we initiate a stage 2 from the perspective of the AUC evaluation where it is not neccessary to initiate one.

If having more than necessary number of subjects is a problem at all? My gut feeling says no.

Regards,

Detlew

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