90% confidence Intervals for IVRT [Nonparametrics]

posted by zizou – Plzeň, Czech Republic, 2017-11-01 20:49 (2339 d 16:11 ago) – Posting: # 17961
Views: 6,647

Dear GM.

First of all, I figured out your link to the reference:
https://www.fda.gov/downloads/drugs/guidances/ucm070930.pdf

Example from page 23 (PDF page 26 of 40).

Lower limit is the 8th value of sorted values and upper limit is 29th value as mentioned in the text (PDF page 27 of 40).

8 is 5th quantile calculated from the equation as you already mentioned:
w(0.05) = mn/2 - zcrit*sqrt(mn*(m+n+1)/12) ... approximation for m+n large enough.

And 29 is 95th quantile + 1. Here you probably forgot "+ 1" to get the right position of upper limit.
In this case there is even count of ordered data.
Lower limit is 8th from the start, upper limit is 8th from the end, i.e. 29th from the start.

So you get the positions of ordered data and then you have lower and upper limit directly, you know.

Best regards,
zizou

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
106 visitors (0 registered, 106 guests [including 5 identified bots]).
Forum time: 13:00 CET (Europe/Vienna)

With four parameters I can fit an elephant,
and with five I can make him wiggle his trunk.    John von Neumann

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5