## PHX/WNL 8.0 vs. previous releases [R for BE/BA]

Hi Astea,

» Can anyone please suggest me an easy way of calculation T

Maybe later.

» By the way, in this old thread as well as in this it was written that Phoenix approximates the decreasing part with log-transformation independetly of the rule choosen for AUC.

Although not described in the User’s Guide, correct.

» Now it seemed to be changed, and the actual form of approximation depends on the rule for AUC, so it can be linear as well as log-linear.

Correct since the current release v8.0 (formulas (6) and (7) on p53 of the User’s Guide).

» But this is not true for partial area calculation: for example, AUC

Like in previous versions (though I didn’t check it)-

» I am also puzzled why for the following dataset we get TimeLow=18 if Lower limit is choosen to be 3? Because if we substract 4 from all time points we'll get 16... (linear interpolation was selected)

»

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Since your data set doesn’t contain a concentration at t=0, it is extrapolated (see the

» Can anyone please suggest me an easy way of calculation T

_{50%}early and late, T_{75%}, T_{90%}and similar parameters via Phoenix?Maybe later.

» By the way, in this old thread as well as in this it was written that Phoenix approximates the decreasing part with log-transformation independetly of the rule choosen for AUC.

Although not described in the User’s Guide, correct.

» Now it seemed to be changed, and the actual form of approximation depends on the rule for AUC, so it can be linear as well as log-linear.

Correct since the current release v8.0 (formulas (6) and (7) on p53 of the User’s Guide).

» But this is not true for partial area calculation: for example, AUC

_{0-72}for subjects with missing t=72 value, Phoenix always do log interpolation even if we've choosen linear AUC calculation.Like in previous versions (though I didn’t check it)-

» I am also puzzled why for the following dataset we get TimeLow=18 if Lower limit is choosen to be 3? Because if we substract 4 from all time points we'll get 16... (linear interpolation was selected)

»

` t | C`

»

`---+---`

»

` 4 | 6`

»

` 6 | 4`

»

` 8 | 3`

»

`10 | 2`

»

`12 | 0`

»

`24 | 0`

Since your data set doesn’t contain a concentration at t=0, it is extrapolated (see the

`core output`

). The method depends on the `Dose Options`

. For `Extravascular`

we get C=0 and for `IV Bolus`

C=13.5. Then I got these results for `TimeLow`

in the releases of Phoenix/WinNonlin I have on my machine:`Dose Options 6.3 6.4 7.0 8.0`

Extravascular 28 28 28 18

IV Bolus 31 31 31 16

—

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮

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*Dif-tor heh smusma*🖖Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮

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### Complete thread:

- Calculation of time above MIC Aceto81 2008-06-26 16:31 [R for BE/BA]
- Calculation of time above MIC Helmut 2008-06-26 18:58
- Calculation of time above MIC Aceto81 2008-06-26 21:50
- Calculation of time above MIC Helmut 2008-06-27 00:18
- Calculation of time above MIC Helmut 2008-06-29 02:24
- Calculation of time above MIC Aceto81 2008-06-30 15:50
- Therapeutic Occupancy Time / MEC Helmut 2008-06-30 16:45

- Calculation of time above MIC Aceto81 2008-06-30 15:50

- Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-08 20:38
- Time above MIC (WinNonlin 5.2.1) Aceto81 2008-08-12 09:56
- Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-12 12:32
- Time above MIC (R function) Aceto81 2008-08-13 11:19
- Time above MIC (R function) Helmut 2008-08-13 13:18
- Time above MIC (R function) Aceto81 2008-08-13 15:35

- Time above MIC (R function) Helmut 2008-08-13 13:18
- Phoenix-WinNonlin 6.0 released 29 May 2009 SDavis 2009-06-04 10:55
- Phoenix-WinNonlin 6.0 Helmut 2009-06-04 11:57
- Phoenix-WinNonlin 6.0 - introductory webinars SDavis 2009-06-04 18:50
- Phoenix-WinNonlin 6.0 - introductory webinars Helmut 2009-06-04 23:40

- Phoenix-WinNonlin 6.0 - introductory webinars SDavis 2009-06-04 18:50

- Phoenix-WinNonlin 6.0 Helmut 2009-06-04 11:57

- Time above MIC (R function) Aceto81 2008-08-13 11:19

- Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-12 12:32
- TimeLow Astea 2017-10-28 22:15
- PHX/WNL 8.0 vs. previous releasesHelmut 2017-10-28 23:20
- PHX/WNL 8.0 vs. previous releases Astea 2017-10-28 23:49

- Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Helmut 2017-10-30 13:18
- Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Astea 2017-10-31 01:12
- Intersections Helmut 2017-10-31 12:32
- nobody needs it... Astea 2017-10-31 18:24

- Intersections Helmut 2017-10-31 12:32

- Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Astea 2017-10-31 01:12

- PHX/WNL 8.0 vs. previous releasesHelmut 2017-10-28 23:20

- Time above MIC (WinNonlin 5.2.1) Aceto81 2008-08-12 09:56

- Calculation of time above MIC Aceto81 2008-06-26 21:50

- Calculation of time above MIC Helmut 2008-06-26 18:58