PHX/WNL 8.0 vs. previous releases [🇷 for BE/BA]
❝ Can anyone please suggest me an easy way of calculation T50% early and late, T75%, T90% and similar parameters via Phoenix?
Maybe later.

❝ By the way, in this old thread as well as in this it was written that Phoenix approximates the decreasing part with log-transformation independetly of the rule choosen for AUC.
Although not described in the User’s Guide, correct.
❝ Now it seemed to be changed, and the actual form of approximation depends on the rule for AUC, so it can be linear as well as log-linear.
Correct since the current release v8.0 (formulas (6) and (7) on p53 of the User’s Guide).
❝ But this is not true for partial area calculation: for example, AUC0-72 for subjects with missing t=72 value, Phoenix always do log interpolation even if we've choosen linear AUC calculation.
Like in previous versions (though I didn’t check it)-
❝ I am also puzzled why for the following dataset we get TimeLow=18 if Lower limit is choosen to be 3? Because if we substract 4 from all time points we'll get 16... (linear interpolation was selected)
❝ t | C
❝ ---+---
❝ 4 | 6
❝ 6 | 4
❝ 8 | 3
❝ 10 | 2
❝ 12 | 0
❝ 24 | 0
Since your data set doesn’t contain a concentration at t=0, it is extrapolated (see the
core output
). The method depends on the Dose Options
. For Extravascular
we get C=0 and for IV Bolus
C=13.5. Then I got these results for TimeLow
in the releases of Phoenix/WinNonlin I have on my machine:Dose Options 6.3 6.4 7.0 8.0
Extravascular 28 28 28 18
IV Bolus 31 31 31 16
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Calculation of time above MIC Aceto81 2008-06-26 16:31 [🇷 for BE/BA]
- Calculation of time above MIC Helmut 2008-06-26 18:58
- Calculation of time above MIC Aceto81 2008-06-26 21:50
- Calculation of time above MIC Helmut 2008-06-27 00:18
- Calculation of time above MIC Helmut 2008-06-29 02:24
- Calculation of time above MIC Aceto81 2008-06-30 15:50
- Therapeutic Occupancy Time / MEC Helmut 2008-06-30 16:45
- Calculation of time above MIC Aceto81 2008-06-30 15:50
- Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-08 20:38
- Time above MIC (WinNonlin 5.2.1) Aceto81 2008-08-12 09:56
- Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-12 12:32
- Time above MIC (R function) Aceto81 2008-08-13 11:19
- Time above MIC (R function) Helmut 2008-08-13 13:18
- Time above MIC (R function) Aceto81 2008-08-13 15:35
- Time above MIC (R function) Helmut 2008-08-13 13:18
- Phoenix-WinNonlin 6.0 released 29 May 2009 SDavis 2009-06-04 10:55
- Phoenix-WinNonlin 6.0 Helmut 2009-06-04 11:57
- Phoenix-WinNonlin 6.0 - introductory webinars SDavis 2009-06-04 18:50
- Phoenix-WinNonlin 6.0 - introductory webinars Helmut 2009-06-04 23:40
- Phoenix-WinNonlin 6.0 - introductory webinars SDavis 2009-06-04 18:50
- Phoenix-WinNonlin 6.0 Helmut 2009-06-04 11:57
- Time above MIC (R function) Aceto81 2008-08-13 11:19
- Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-12 12:32
- TimeLow Astea 2017-10-28 22:15
- PHX/WNL 8.0 vs. previous releasesHelmut 2017-10-28 23:20
- PHX/WNL 8.0 vs. previous releases Astea 2017-10-28 23:49
- Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Helmut 2017-10-30 13:18
- Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Astea 2017-10-31 01:12
- Intersections Helmut 2017-10-31 12:32
- nobody needs it... Astea 2017-10-31 18:24
- Intersections Helmut 2017-10-31 12:32
- Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Astea 2017-10-31 01:12
- PHX/WNL 8.0 vs. previous releasesHelmut 2017-10-28 23:20
- Time above MIC (WinNonlin 5.2.1) Aceto81 2008-08-12 09:56
- Calculation of time above MIC Aceto81 2008-06-26 21:50
- Calculation of time above MIC Helmut 2008-06-26 18:58