Bioequivalence and Bioavailability Forum • PHX/WNL 8.0 vs. previous releases

PHX/WNL 8.0 vs. previous releases [🇷 for BE/BA]

posted by Helmut – Vienna, Austria, 2017-10-29 01:20 (2361 d 06:12 ago) – Posting: # 17939
Views: 22,841

Hi Astea,

❝ Can anyone please suggest me an easy way of calculation T_50% early and late, T_75%, T_90% and similar parameters via Phoenix?

Maybe later. ;-)

❝ By the way, in this old thread as well as in this it was written that Phoenix approximates the decreasing part with log-transformation independetly of the rule choosen for AUC.

Although not described in the User’s Guide, correct.

❝ Now it seemed to be changed, and the actual form of approximation depends on the rule for AUC, so it can be linear as well as log-linear.

Correct since the current release v8.0 (formulas (6) and (7) on p53 of the User’s Guide).

❝ But this is not true for partial area calculation: for example, AUC_0-72 for subjects with missing t=72 value, Phoenix always do log interpolation even if we've choosen linear AUC calculation.

Like in previous versions (though I didn’t check it)-

❝ I am also puzzled why for the following dataset we get TimeLow=18 if Lower limit is choosen to be 3? Because if we substract 4 from all time points we'll get 16... (linear interpolation was selected)

❝ t | C

❝ ---+---

❝ 4 | 6

❝ 6 | 4

❝ 8 | 3

❝ 10 | 2

❝ 12 | 0

❝ 24 | 0

Since your data set doesn’t contain a concentration at t=0, it is extrapolated (see the core output). The method depends on the Dose Options. For Extravascular we get C=0 and for IV Bolus C=13.5. Then I got these results for TimeLow in the releases of Phoenix/WinNonlin I have on my machine:

Dose Options 6.3 6.4 7.0 8.0 Extravascular 28 28 28 18 IV Bolus 31 31 31 16

I will explore it further…

—
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Helmut Schütz

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Complete thread:

Calculation of time above MIC Aceto81 2008-06-26 16:31 [🇷 for BE/BA]
- Calculation of time above MIC Helmut 2008-06-26 18:58
  - Calculation of time above MIC Aceto81 2008-06-26 21:50
    - Calculation of time above MIC Helmut 2008-06-27 00:18
    - Calculation of time above MIC Helmut 2008-06-29 02:24
      - Calculation of time above MIC Aceto81 2008-06-30 15:50
        
        Therapeutic Occupancy Time / MEC Helmut 2008-06-30 16:45
  - Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-08 20:38
    - Time above MIC (WinNonlin 5.2.1) Aceto81 2008-08-12 09:56
      - Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-12 12:32
        
        Time above MIC (R function) Aceto81 2008-08-13 11:19
        
        Time above MIC (R function) Helmut 2008-08-13 13:18
        
        Time above MIC (R function) Aceto81 2008-08-13 15:35
        
        Phoenix-WinNonlin 6.0 released 29 May 2009 SDavis 2009-06-04 10:55
        
        Phoenix-WinNonlin 6.0 Helmut 2009-06-04 11:57
        
        Phoenix-WinNonlin 6.0 - introductory webinars SDavis 2009-06-04 18:50
        
        Phoenix-WinNonlin 6.0 - introductory webinars Helmut 2009-06-04 23:40
    - TimeLow Astea 2017-10-28 22:15
      - PHX/WNL 8.0 vs. previous releasesHelmut 2017-10-28 23:20
        
        PHX/WNL 8.0 vs. previous releases Astea 2017-10-28 23:49
      - Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Helmut 2017-10-30 13:18
        
        Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Astea 2017-10-31 01:12
        
        Intersections Helmut 2017-10-31 12:32
        
        nobody needs it... Astea 2017-10-31 18:24