Bioequivalence and Bioavailability Forum

Dear Öberster Größter Meister, Nobody!

❝ ... Planning a BE-study should involve that you know that the "correct" GMR / sample size is hindsight knowledge ...

You never know the population values of CV and/or GMR you need to have a reliable sample size estimation. You always rely on assumptions / guesses, educated or not / gut feeling or whatever else for these values. If this is scientific is left to you. Default or not .

And remember: At the end of the day the sponsor (with or without Armani suite) is always right.
I never came across with cases where the sponsor desired sample size was not "scientifically" estimated and justified.
"Power Calculation - A guess masquerading as mathematics." Stephen Senn
Remember the BOSS button in Dave's Fartssie.xls! More than once I was asked to introduce such tool in PowerTOST.

Nevertheless you may contact the Maintainer of PowerTOST and suggest changes or create an issue on GitHub. Best to suggest to abstain from all defaults including alpha=0.05 or the BE acceptance limits 0.8 ... 1.25 to force the user to think about those settings.
But be warned. It's best not to tangle that Maintainer guy without an Armani suite. May be he is biting back .