Bioequivalence and Bioavailability Forum

Nitpicker! [Two-Stage / GS Designs]

posted by ElMaestro  – Denmark, 2017-08-22 19:27 (2437 d 22:50 ago) – Posting: # 17733
Views: 27,164

Hi Hötzi,

❝ You have a point. IMHO, this question should be answered: yes!

And on basis of this story we will define Hötzi's universal law of BE:
ElMaestro is always right¹.


By the way, since you are a speed devotee:
FindCritCV.Sec=function(Pwr.T, GMR, Nps, Is.St2=1, d=.00001, iniCV)
##the secant method has really nasty properties if the ini value is a little off.
{
  CV1=iniCV
  CV2=CV1*1.05
  y2=1
  while (abs(y2)>d)
  {
   y1=Power.calc(Nps, GMR, CV1, Is.St2)-Pwr.T
   y2=Power.calc(Nps, GMR, CV2, Is.St2)-Pwr.T
   CV3= CV2-y2*(CV2-CV1)/(y2-y1)
   CV1=CV2
   CV2=CV3
  }
  return(0.5*(CV1+CV2)) ##or play around
}

(...)
 for (Nps in 6:length(vecCritCVs))
  {
   if (Nps==6) iniCV=min(0.709*GMR-0.552, 0.709/GMR -0.552)
               else iniCV=vecCritCVs[Nps-1]
    vecCritCVs[Nps]<<-FindCritCV.Sec(0.8, GMR, Nps, 1, 1e-10, iniCV)
  }

(...)















Footnote 1:
Except when he isn't. Which also happens. With regrettable frequency...

Complete thread:

• Initial sample size guess for the Potvin methods ElMaestro 2017-08-19 15:04 
  • Initial sample size guess for the Potvin methods Helmut 2017-08-19 16:06
    • Initial sample size guess for the Potvin methods ElMaestro 2017-08-19 16:14
      • Initial sample size guess for the Potvin methods Helmut 2017-08-19 17:12
        • Initial sample size guess for the Potvin methods ElMaestro 2017-08-19 17:17
          • Confuse-a-Cat Helmut 2017-08-19 17:33
            • Confuse-a-Cat ElMaestro 2017-08-19 17:56
      • loop ↔ vectorized ↔ direct Helmut 2017-08-20 14:40
        • loop ↔ vectorized ↔ direct ElMaestro 2017-08-20 15:22
          • loop ↔ vectorized ↔ direct Helmut 2017-08-20 16:23
            • loop ↔ vectorized ↔ direct ElMaestro 2017-08-20 17:22
  • The n ext crackpot iteration ElMaestro 2017-08-19 20:04
    • The n ext crackpot iteration Helmut 2017-08-20 02:20
  • The ultimate crackpot iteration! ElMaestro 2017-08-20 14:35
    • The ultimate crackpot iteration! Helmut 2017-08-20 15:11
      • The ultimate crackpot iteration! ElMaestro 2017-08-20 15:28
        • The ultimate crackpot iteration! Helmut 2017-08-20 16:06
          • The ultimate crackpot iteration! ElMaestro 2017-08-20 16:15
            • The ultimate crackpot iteration! Helmut 2017-08-20 18:58
              • The ultimate crackpot iteration! ElMaestro 2017-08-20 19:32
                • Suggested code ElMaestro 2017-08-21 18:13
                  • Nitpicker! Helmut 2017-08-22 13:33
                    • Nitpicker!ElMaestro 2017-08-22 17:27
                      • Nitpicker! Helmut 2017-08-22 17:49
                        • Nitpicker! ElMaestro 2017-08-22 17:59
                          • Nitpicker! Helmut 2017-08-22 19:15
                            • Benchmark code ElMaestro 2017-08-22 22:29
                              • Benchmark code Helmut 2017-08-23 01:48