Bioequivalence and Bioavailability Forum • Confuse-a-Cat

Confuse-a-Cat [Two-Stage / GS Designs]

posted by ElMaestro – Denmark, 2017-08-19 19:56 (2439 d 21:33 ago) – Posting: # 17715
Views: 27,773

Hi again,

❝ Now I get it – though your code is beyond me. Zhang’s method in many cases hits the right point in the first attempt. Sometimes sampleN.TOST() has to iterate upwards (since Zhang’s method is based on a large sample approximation and power with anything of the t-family will be lower). In very rare cases sampleN.TOST() has to iterate downwards. Can your code do that as well?

Yes. Basically, get the initial initial guess, determine if it is low or high for the desired power, iterate up or down depending on that.

The reason I am doing this is I got a mental "Does not compute error" when I read Zhang's paper. The goal is to get to the right sample size in as few cycles as possible.

—
Pass or fail!
ElMaestro

Complete thread:

Initial sample size guess for the Potvin methods ElMaestro 2017-08-19 15:04
- Initial sample size guess for the Potvin methods Helmut 2017-08-19 16:06
  - Initial sample size guess for the Potvin methods ElMaestro 2017-08-19 16:14
    - Initial sample size guess for the Potvin methods Helmut 2017-08-19 17:12
      - Initial sample size guess for the Potvin methods ElMaestro 2017-08-19 17:17
        
        Confuse-a-Cat Helmut 2017-08-19 17:33
        
        Confuse-a-CatElMaestro 2017-08-19 17:56
    - loop ↔ vectorized ↔ direct Helmut 2017-08-20 14:40
      - loop ↔ vectorized ↔ direct ElMaestro 2017-08-20 15:22
        
        loop ↔ vectorized ↔ direct Helmut 2017-08-20 16:23
        
        loop ↔ vectorized ↔ direct ElMaestro 2017-08-20 17:22
- The n ext crackpot iteration ElMaestro 2017-08-19 20:04
  - The n ext crackpot iteration Helmut 2017-08-20 02:20
- The ultimate crackpot iteration! ElMaestro 2017-08-20 14:35
  - The ultimate crackpot iteration! Helmut 2017-08-20 15:11
    - The ultimate crackpot iteration! ElMaestro 2017-08-20 15:28
      - The ultimate crackpot iteration! Helmut 2017-08-20 16:06
        
        The ultimate crackpot iteration! ElMaestro 2017-08-20 16:15
        
        The ultimate crackpot iteration! Helmut 2017-08-20 18:58
        
        The ultimate crackpot iteration! ElMaestro 2017-08-20 19:32
        
        Suggested code ElMaestro 2017-08-21 18:13
        
        Nitpicker! Helmut 2017-08-22 13:33
        
        Nitpicker! ElMaestro 2017-08-22 17:27
        
        Nitpicker! Helmut 2017-08-22 17:49
        
        Nitpicker! ElMaestro 2017-08-22 17:59
        
        Nitpicker! Helmut 2017-08-22 19:15
        
        Benchmark code ElMaestro 2017-08-22 22:29
        
        Benchmark code Helmut 2017-08-23 01:48