Bioequivalence and Bioavailability Forum • Don’t use the formula by Chow, Shao, Wang!

Don’t use the formula by Chow, Shao, Wang! [Power / Sample Size]

posted by daryazyatina – Ukraine, 2017-08-03 17:52 (2784 d 07:20 ago) – Posting: # 17654
Views: 19,867

Hi, Helmut

❝ Stop using the formula given by Chow, Shao, Wang! Sample sizes are way too small – which compromises power. If you used it in the past for 80% power – if all assumptions (CV, θ₀) turned out to be “correct” – substantially more than 20% of studies should have failed. If not, you were lucky!

Thank you for such a comprehensive answer.
It's good that now we will know about this.

Complete thread:

sample size in bioequivalence studies daryazyatina 2017-08-03 09:34 [Power / Sample Size]
- sample size in bioequivalence studies BE-proff 2017-08-03 09:55
  - sample size in bioequivalence studies daryazyatina 2017-08-03 10:08
- sample size in bioequivalence studies ElMaestro 2017-08-03 10:17
  - sample size in bioequivalence studies daryazyatina 2017-08-03 10:58
    - sample size in bioequivalence studies DavidManteigas 2017-08-03 12:40
      - sample size in bioequivalence studies daryazyatina 2017-08-03 13:46
      - Don’t use the formula by Chow, Shao, Wang! Helmut 2017-08-03 15:37
        
        Don’t use the formula by Chow, Shao, Wang!daryazyatina 2017-08-03 15:52
        Don’t use the formula by Chow, Shao, Wang! DavidManteigas 2017-08-03 16:12
        
        Don’t use the formula by Chow, Shao, Wang! Helmut 2017-08-03 16:33
        
        Don’t use the Book by Chow, Shao, Wang! d_labes 2017-08-16 16:01
    - compromised power Helmut 2017-08-03 16:04
      - compromised power daryazyatina 2017-08-04 08:15
        
        terminology Helmut 2017-08-04 12:41
        
        terminology daryazyatina 2017-08-16 10:12
        
        terminology Helmut 2017-08-16 18:54
- sample size in bioequivalence studies balinskyi 2018-06-03 12:58