## sample size in bioequivalence studies [Power / Sample Size]

Hi, guys!

Today I have a new question related to the the sample size formula for average bioequivalence.

Before now I сalculated the sample size for ABE by formula:

(described in the book Shein-Chung Chow, Jun Shao and Hansheng Wang "Sample size calculations in clinical research" Copyright © 2003 by Marcel Dekker (Chapter 10. Bioequivalence Testing) http://www.crcnetbase.com/doi/book/10.1201/9780203911341)

I decided to try to calculate the sample size in R with package "PowerTOST" and function

Comparing the results of the calculation in R and calculation with formula Shein-Chung Chow, Jun Shao and Hansheng Wang, I realized that they are different. I looked at the articles and books that this function refers to, and understand that different formulas are used.

On this basis, I had a question. What formula should I use to calculate the sample size for the ABE using two one-sided tests?

Today I have a new question related to the the sample size formula for average bioequivalence.

Before now I сalculated the sample size for ABE by formula:

(described in the book Shein-Chung Chow, Jun Shao and Hansheng Wang "Sample size calculations in clinical research" Copyright © 2003 by Marcel Dekker (Chapter 10. Bioequivalence Testing) http://www.crcnetbase.com/doi/book/10.1201/9780203911341)

I decided to try to calculate the sample size in R with package "PowerTOST" and function

`sampleN.TOST()`

Comparing the results of the calculation in R and calculation with formula Shein-Chung Chow, Jun Shao and Hansheng Wang, I realized that they are different. I looked at the articles and books that this function refers to, and understand that different formulas are used.

On this basis, I had a question. What formula should I use to calculate the sample size for the ABE using two one-sided tests?

### Complete thread:

- sample size in bioequivalence studiesdaryazyatina 2017-08-03 09:34 [Power / Sample Size]
- sample size in bioequivalence studies BE-proff 2017-08-03 09:55
- sample size in bioequivalence studies daryazyatina 2017-08-03 10:08

- sample size in bioequivalence studies ElMaestro 2017-08-03 10:17
- sample size in bioequivalence studies daryazyatina 2017-08-03 10:58
- sample size in bioequivalence studies DavidManteigas 2017-08-03 12:40
- sample size in bioequivalence studies daryazyatina 2017-08-03 13:46
- Don’t use the formula by Chow, Shao, Wang! Helmut 2017-08-03 15:37
- Don’t use the formula by Chow, Shao, Wang! daryazyatina 2017-08-03 15:52
- Don’t use the formula by Chow, Shao, Wang! DavidManteigas 2017-08-03 16:12
- Don’t use the formula by Chow, Shao, Wang! Helmut 2017-08-03 16:33

- Don’t use the Book by Chow, Shao, Wang! d_labes 2017-08-16 16:01

- compromised power Helmut 2017-08-03 16:04
- compromised power daryazyatina 2017-08-04 08:15
- terminology Helmut 2017-08-04 12:41
- terminology daryazyatina 2017-08-16 10:12
- terminology Helmut 2017-08-16 18:54

- terminology daryazyatina 2017-08-16 10:12

- terminology Helmut 2017-08-04 12:41

- compromised power daryazyatina 2017-08-04 08:15

- sample size in bioequivalence studies DavidManteigas 2017-08-03 12:40

- sample size in bioequivalence studies daryazyatina 2017-08-03 10:58
- sample size in bioequivalence studies balinskyi 2018-06-03 12:58

- sample size in bioequivalence studies BE-proff 2017-08-03 09:55