T1 and T2 of TOST [General Statistics]
Salam Mohamed,
Correct for a parallel design, wrong for a 2×2×2 crossover. Use these ones:
BTW, consider reading the original paper* instead of trusting in what you find on the internet (including this site, of course).
❝ I want to know how to calculate the T1 and T2 of schuirmann test for 2*2 crossover bioequivalence study.... I found this equation, i want to know whether it is correct or wrong?.
Correct for a parallel design, wrong for a 2×2×2 crossover. Use these ones:
where YT and YR are the geometric least squares (aka marginal, adjusted) means of T and R, θ1 and θ2 the lower und upper limits of the acceptance range, σw the √MSE from ANOVA, and n1, n2 the number of subjects / sequence.
BTW, consider reading the original paper* instead of trusting in what you find on the internet (including this site, of course).
- Schuirmann DJ. A comparison of the Two One-Sided Tests Procedure and the Power Approach for Assessing the Equivalence of Average Bioavailability. J Pharmacokin Biopharm. 1987;15(6):657–80. doi:10.1007/BF01068419.
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
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The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:
- T1 and T2 of Schuirmann test for bioequivalence Mohamed Yehia 2017-07-28 21:00 [General Statistics]
- T1 and T2 of TOSTHelmut 2017-07-29 01:09
- T1 and T2 of TOST Mohamed Yehia 2017-07-29 20:38
- T1 and T2 of TOSTHelmut 2017-07-29 01:09