## Power Calculation for replicate crossover design [R for BE/BA]

Dear Matz,

you will get the same power in N subjects (TRRT|RTTR) as compared to a 2×2×2 design in N subjects (half the sample size - but same number of treatments!). If you perform a study in a 2-treatment 2-sequence 3-period design (e.g., TRT|RTR) the same power is obtained in N subjects.1)
1. László Tóthfalusi
Scaled Average Bioequivalence to Evaluate Bioequivalence of Highly Variable Drugs
Presentation given at “Dissolution Testing, Bioavailability & Bioequivalence Conference”
Budapest, May 24th, 2007

Dif-tor heh smusma 🖖
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
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