Power Calculation for replicate crossover design [R for BE/BA]

posted by Helmut Homepage – Vienna, Austria, 2008-04-03 13:49  – Posting: # 1758
Views: 33,210

Dear Matz,

you will get the same power in N subjects (TRRT|RTTR) as compared to a 2×2×2 design in N subjects (half the sample size - but same number of treatments!). If you perform a study in a 2-treatment 2-sequence 3-period design (e.g., TRT|RTR) the same power is obtained in N subjects.1)
  1. László Tóthfalusi
    Scaled Average Bioequivalence to Evaluate Bioequivalence of Highly Variable Drugs
    Presentation given at “Dissolution Testing, Bioavailability & Bioequivalence Conference”
    Budapest, May 24th, 2007

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

 Admin contact
20,646 posts in 4,328 threads, 1,436 registered users;
online 14 (0 registered, 14 guests [including 3 identified bots]).
Forum time: 19:25 CEST (Europe/Vienna)

No one should approach the temple of science
with the soul of a money changer.    Thomas Browne

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz