Power Calculation for replicate crossover design [R for BE/BA]

posted by Helmut Homepage – Vienna, Austria, 2008-04-03 13:49  – Posting: # 1758
Views: 28,651

Dear Matz,

you will get the same power in N subjects (TRRT|RTTR) as compared to a 2×2×2 design in N subjects (half the sample size - but same number of treatments!). If you perform a study in a 2-treatment 2-sequence 3-period design (e.g., TRT|RTR) the same power is obtained in N subjects.1)
  1. László Tóthfalusi
    Scaled Average Bioequivalence to Evaluate Bioequivalence of Highly Variable Drugs
    Presentation given at “Dissolution Testing, Bioavailability & Bioequivalence Conference”
    Budapest, May 24th, 2007

Cheers,
Helmut Schütz
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