## Power Calculation for replicate crossover design [R for BE/BA]

Dear Matz,

you will get the same power in ~½N subjects (TRRT|RTTR) as compared to a 2×2×2 design in N subjects (half the sample size - but same number of treatments!). If you perform a study in a 2-treatment 2-sequence 3-period design (

you will get the same power in ~½N subjects (TRRT|RTTR) as compared to a 2×2×2 design in N subjects (half the sample size - but same number of treatments!). If you perform a study in a 2-treatment 2-sequence 3-period design (

*e.g.*, TRT|RTR) the same power is obtained in ~¾N subjects.^{1)}

**László Tóthfalusi**

*Scaled Average Bioequivalence to Evaluate Bioequivalence of Highly Variable Drugs*

Presentation given at “Dissolution Testing, Bioavailability & Bioequivalence Conference”

Budapest, May 24^{th}, 2007

—

Cheers,

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. ☼

Science Quotes

Cheers,

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. ☼

Science Quotes

### Complete thread:

- R-Code for Power in 2×2 Cross-over Helmut 2006-12-28 21:33 [R for BE/BA]
- Power in Diletti's sample size table Helmut 2007-01-01 23:59
- Approximate Power Helmut 2007-01-06 15:17
- Power Calculation for replicate crossover design mathews 2008-04-03 13:19
- Power Calculation for replicate crossover design Helmut 2008-04-03 13:49
- Power Calculation for replicate crossover design mathews 2008-04-04 13:21

- Power Calculation for replicate crossover design Helmut 2008-04-03 13:49
- Exact Power Helmut 2009-09-25 19:20
- Exact Power ElMaestro 2009-09-27 23:27
- Software validation Helmut 2009-09-28 15:21
- All the important answers are here! ElMaestro 2009-09-28 19:12
- All the important answers are here! Helmut 2009-09-28 19:52
- All the important answers are here! ElMaestro 2009-09-28 20:18
- All the important answers are here! yjlee168 2009-09-28 21:30
- All the important answers are here! Helmut 2009-09-28 23:18
- 42! SASophylistic power oracle d_labes 2009-09-29 13:37
- Al Gore Rhythms Helmut 2009-09-29 14:52
- Al Gore Rhythms ElMaestro 2009-09-29 18:14
- Al Gore Rhythms yjlee168 2009-09-29 23:55

- Al Gore Rhythms Helmut 2009-09-29 14:52

- 42! SASophylistic power oracle d_labes 2009-09-29 13:37
- All the important answers are here! yjlee168 2009-09-29 23:49

- All the important answers are here! Helmut 2009-09-28 23:18

- All the important answers are here! Helmut 2009-09-28 19:52

- All the important answers are here! ElMaestro 2009-09-28 19:12

- Software validation Helmut 2009-09-28 15:21

- Exact Power ElMaestro 2009-09-27 23:27

- Power Calculation for replicate crossover design mathews 2008-04-03 13:19

- Approximate Power Helmut 2007-01-06 15:17
- R-Code for Power in 2×2 Cross-over KDA 2019-01-23 04:24
- R-Code for Power in 2×2 Cross-over Ohlbe 2019-01-27 18:24

- Power in Diletti's sample size table Helmut 2007-01-01 23:59