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RegisterPower Calculation for replicate crossover design [🇷 for BE/BA]
posted by Helmut 
– Vienna, Austria, 2008-04-03 15:49 (6284 d 20:10 ago) – Posting: # 1758
Views: 49,055
Dear Matz,
you will get the same power in ~½N subjects (TRRT|RTTR) as compared to a 2×2×2 design in N subjects (half the sample size - but same number of treatments!). If you perform a study in a 2-treatment 2-sequence 3-period design (e.g., TRT|RTR) the same power is obtained in ~¾N subjects.
you will get the same power in ~½N subjects (TRRT|RTTR) as compared to a 2×2×2 design in N subjects (half the sample size - but same number of treatments!). If you perform a study in a 2-treatment 2-sequence 3-period design (e.g., TRT|RTR) the same power is obtained in ~¾N subjects.
1)- László Tóthfalusi
Scaled Average Bioequivalence to Evaluate Bioequivalence of Highly Variable Drugs
Presentation given at “Dissolution Testing, Bioavailability & Bioequivalence Conference”
Budapest, May 24th, 2007
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Helmut Schütz
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Helmut Schütz
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Ing. Helmut Schütz