Between-batch precision – a misnomer? [Bioanalytics]
Although not specifically addressed **cough**, I would add to the discussion some old-school knowledge on validation:
Method validation in the bioanalytical laboratory. Buick AR, Doig MV, Jeal SC, Land GS, McDowall RD. J Pharm Biomed Anal. 1990;8(8-12):629-37.
Shah VP, Midha KK, Dighe S, et al. Analytical method validation: bioavailability, bioequivalence, and pharmacokinetic studies. J Pharm Sci. 1992;81:309–312.
What is determined by the methodology described would be "Vergleichspräzision" in Tschörman. It's an old tradition and describes some kind of precision on more than one day/one calibration. There are gazillions of ways to determine variabilities, including/excluding error propagation.
In the end of the day it's only kind of convention how to do it.
Usual way: Problem -> solution. If no problem, don't look for solution
Method validation in the bioanalytical laboratory. Buick AR, Doig MV, Jeal SC, Land GS, McDowall RD. J Pharm Biomed Anal. 1990;8(8-12):629-37.
Shah VP, Midha KK, Dighe S, et al. Analytical method validation: bioavailability, bioequivalence, and pharmacokinetic studies. J Pharm Sci. 1992;81:309–312.
What is determined by the methodology described would be "Vergleichspräzision" in Tschörman. It's an old tradition and describes some kind of precision on more than one day/one calibration. There are gazillions of ways to determine variabilities, including/excluding error propagation.
In the end of the day it's only kind of convention how to do it.
Usual way: Problem -> solution. If no problem, don't look for solution

—
Kindest regards, nobody
Kindest regards, nobody
Complete thread:
- Between-batch precision – a misnomer? ElMaestro 2017-07-14 10:37 [Bioanalytics]
- Between-batch precision – a misnomer?nobody 2017-07-15 16:31
- State with a single sentence ElMaestro 2017-07-15 18:00
- State with a single sentence nobody 2017-07-15 20:03
- Yes, definitively Ohlbe 2017-07-16 02:23
- Revised nomenclature ElMaestro 2017-07-16 12:47