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RegisterIntersubject variation in replicated BE study [General Statistics]
Dear d_labes
Thank you for solving the puzzle.
I checked it in comparing to the CSH parameterization in which we had Var(1) and Var(2) as sig_BR2=G(1,1)=Var(1)
sig_BT2=G(2,2)=Var(2).
I referred Design and Anaysis of BA and BE Studies Second Edition by CHOW & LIU (Page 405) for Subject by formulation interaction which confirmed CSH model for
sig_D2=Var(1)+Var(2)-2*CSH*sqrt(Var(1))*sqrt(Var(2)).
We are not going for individual bioequivalence is was only for the sake of my understanding.
I would like to study in detail about Average, Population and Individual bioequivalence. Kindly send some reference for the same.
Regards,
Atish
Thank you for solving the puzzle.
I checked it in comparing to the CSH parameterization in which we had Var(1) and Var(2) as sig_BR2=G(1,1)=Var(1)
sig_BT2=G(2,2)=Var(2).
I referred Design and Anaysis of BA and BE Studies Second Edition by CHOW & LIU (Page 405) for Subject by formulation interaction which confirmed CSH model for
sig_D2=Var(1)+Var(2)-2*CSH*sqrt(Var(1))*sqrt(Var(2)).
We are not going for individual bioequivalence is was only for the sake of my understanding.
I would like to study in detail about Average, Population and Individual bioequivalence. Kindly send some reference for the same.
Regards,
Atish
Complete thread:
- Intersubject variation in replicated BE study atish_azad 2008-03-20 11:33
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Intersubject variation in replicated BE study d_labes 2008-03-26 13:34
- Intersubject variation in replicated BE study atish_azad 2008-03-31 15:02
- Intersubject variation in replicated BE study Jaime_R 2008-03-31 15:09
- Intersubject variation in replicated BE study atish_azad 2008-04-01 06:15
- Intersubject variation in replicated BE study d_labes 2008-04-01 10:01
- Intersubject variation in replicated BE studyatish_azad 2008-04-02 15:27
- Intersubject variation in replicated BE study Jaime_R 2008-03-31 15:09
- Intersubject variation in replicated BE study atish_azad 2008-03-31 15:02
- Intersubject variation in replicated BE study d_labes 2008-03-26 13:34
Ing. Helmut Schütz