Dissolution profie matching [Dissolution / BCS / IVIVC]
Hello everyone?
I am developing a generic formulation with drug containing high soluble polymorphic form than the reference product and having difficulty in matching end stage of drug release.
Reference product is showing around 52 % whereas test product is showing 96% release at 90 minutes ??
Any suggestions???
I am developing a generic formulation with drug containing high soluble polymorphic form than the reference product and having difficulty in matching end stage of drug release.
Reference product is showing around 52 % whereas test product is showing 96% release at 90 minutes ??
Any suggestions???
Complete thread:
- Dissolution profie matchingKiran 2017-06-24 18:25 [Dissolution / BCS / IVIVC]
- in vivo data before tweaking in vitro Helmut 2017-06-24 19:30
- in vivo data before tweaking in vitro Kiran 2017-06-24 20:19
- locally acting / diss. similarity mandatory Helmut 2017-06-25 12:48
- locally acting / diss. similarity mandatory Kiran 2017-06-25 16:40
- locally acting / diss. similarity mandatory Helmut 2017-06-25 12:48
- in vivo data before tweaking in vitro Kiran 2017-06-24 20:19
- Dissolution profie matching ElMaestro 2017-06-25 20:21
- Dissolution profie matching Kiran 2017-06-26 05:11
- in vivo data before tweaking in vitro Helmut 2017-06-24 19:30