Bioequivalence and Bioavailability Forum • increased solubility = different PK profile?

increased solubility = different PK profile? [Dissolution / BCS / IVIVC]

posted by nobody – 2017-06-08 20:57 (2806 d 12:11 ago) – Posting: # 17471
Views: 14,822

Hmmm, but with lower than REF systemic exposure you should not be able to proof efficacy, I guess?

—
Kindest regards, nobody

Complete thread:

increased solubility = different PK profile? Dr_Dan 2017-06-08 16:57 [Dissolution / BCS / IVIVC]
- increased solubility = different PK profile? nobody 2017-06-08 17:16
- increased solubility = different PK profile? Helmut 2017-06-08 17:18
  - increased solubility = different PK profile? nobody 2017-06-08 17:22
    - ka vs. Cmax Helmut 2017-06-09 14:35
      - ka vs. Cmax nobody 2017-06-09 16:27
      - ka vs. Cmax mittyri 2017-06-10 14:59
- increased solubility = different PK profile? ElMaestro 2017-06-08 17:24
  - increased solubility = different PK profile? Dr_Dan 2017-06-08 17:36
    - increased solubility = different PK profile? nobody 2017-06-08 17:43
    - increased solubility = different PK profile? Ohlbe 2017-06-08 18:23
      - increased solubility = different PK profile? nobody 2017-06-08 18:58
    - increased solubility = different PK profile? ElMaestro 2017-06-08 18:45
      - increased solubility = different PK profile?nobody 2017-06-08 18:57
        
        increased solubility = different PK profile? nobody 2017-06-09 09:38
- increased solubility = different PK profile? Kiran 2017-06-24 11:02

Admin contact
23,380 posts in 4,914 threads, 1,661 registered users;
30 visitors (0 registered, 30 guests [including 4 identified bots]).
Forum time: 08:09 CET (Europe/Vienna)

Everything is trivial, if you know the answer. Thomas Jaki

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC

Ing. Helmut Schütz