Bioequivalence and Bioavailability Forum • increased solubility = different PK profile?

increased solubility = different PK profile? [Dissolution / BCS / IVIVC]

posted by Dr_Dan – Germany, 2017-06-08 19:36 (2844 d 01:56 ago) – Posting: # 17466
Views: 14,925

O.k., I see I need to add some more information. The idea behind this question is to develop an oral formulation with a less drug load than the reference product but with the same bioavailability in order to decrease non-systemic adverse events.

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Kind regards and have a nice day
Dr_Dan

Complete thread:

increased solubility = different PK profile? Dr_Dan 2017-06-08 16:57 [Dissolution / BCS / IVIVC]
- increased solubility = different PK profile? nobody 2017-06-08 17:16
- increased solubility = different PK profile? Helmut 2017-06-08 17:18
  - increased solubility = different PK profile? nobody 2017-06-08 17:22
    - ka vs. Cmax Helmut 2017-06-09 14:35
      - ka vs. Cmax nobody 2017-06-09 16:27
      - ka vs. Cmax mittyri 2017-06-10 14:59
- increased solubility = different PK profile? ElMaestro 2017-06-08 17:24
  - increased solubility = different PK profile?Dr_Dan 2017-06-08 17:36
    - increased solubility = different PK profile? nobody 2017-06-08 17:43
    - increased solubility = different PK profile? Ohlbe 2017-06-08 18:23
      - increased solubility = different PK profile? nobody 2017-06-08 18:58
    - increased solubility = different PK profile? ElMaestro 2017-06-08 18:45
      - increased solubility = different PK profile? nobody 2017-06-08 18:57
        
        increased solubility = different PK profile? nobody 2017-06-09 09:38
- increased solubility = different PK profile? Kiran 2017-06-24 11:02