Bioequivalence and Bioavailability Forum

Dear nobody,

❝ IIRC there are practical limitations WRT to obtaining plasma (size of Monvette, centrifugation, hemolysis, pipetting/storage of plasma?) so: not so easy to downsize in practice, I think.

3 ml vacutainers are commercially available with the usual anticoagulants (EDTA, Li heparin). No additional risk of hemolysis, AFAIK. Storage of plasma: I would definitively avoid 5 ml tubes... There are some very convenient smaller tubes with a screw cap and a conic bottom, already in common use at a number of places. It also saves space in freezers which can compensate the additional cost of such tubes.