sample size calculation by WinNonLin [Software]

posted by Helmut Homepage – Vienna, Austria, 2008-04-01 16:08 (6648 d 12:36 ago) – Posting: # 1740
Views: 7,595

Dear Manoj!

❝ What are the different parameter from the WinNonLin bioequivalence output

❝ can be used for the calculation of sample size for a pivotal study [...]



You need CVintra and the point estimate (PE).
In WinNonlin's terminology:
    Intrasubject CV and Ratio(%Ref)
For a 2×2 design CVintra is directly given in the output (example in this post), for a William's design (more than two treatments, unreplicated) you have to calculate it manually from the residual variance (example in this post).

❝ [...] or is it possible to get sample size output from WinNonLin.


No. You will have to use tables, approximations or specialized software. Please search the forum for further informations.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,653 posts in 4,991 threads, 1,570 registered users;
151 visitors (0 registered, 151 guests [including 33 identified bots]).
Forum time: 04:44 CEST (Europe/Vienna)

The idea is to try and give all the information to help others
to judge the value of your contribution;
not just the information that leads to judgment
in one particular direction or another.    Richard Feynman

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5