sample size calculation by WinNonLin [Software]
Dear Manoj!
You need CVintra and the point estimate (PE).
In WinNonlin's terminology:
For a 2×2 design CVintra is directly given in the output (example in this post), for a William's design (more than two treatments, unreplicated) you have to calculate it manually from the residual variance (example in this post).
No. You will have to use tables, approximations or specialized software. Please search the forum for further informations.
❝ What are the different parameter from the WinNonLin bioequivalence output
❝ can be used for the calculation of sample size for a pivotal study [...]
You need CVintra and the point estimate (PE).
In WinNonlin's terminology:
Intrasubject CV
and Ratio(%Ref)
For a 2×2 design CVintra is directly given in the output (example in this post), for a William's design (more than two treatments, unreplicated) you have to calculate it manually from the residual variance (example in this post).
❝ [...] or is it possible to get sample size output from WinNonLin.
No. You will have to use tables, approximations or specialized software. Please search the forum for further informations.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- sample size calculation by WinNonLin manojkarwa 2008-04-01 13:31 [Software]
- sample size calculation by WinNonLinHelmut 2008-04-01 14:08
- sample size calculation by WinNonLin manojkarwa 2008-04-02 08:48
- Reference for sample size calculation Helmut 2008-04-02 11:06
- sample size calculation by WinNonLin manojkarwa 2008-04-02 08:48
- sample size calculation by WinNonLinHelmut 2008-04-01 14:08